TargetMol

CDK8-IN-13

Product Code:
 
TAR-T72029
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T72029-1mg1mg£101.00
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Quantity:
TAR-T72029-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T72029-5mg5mg£147.00
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TAR-T72029-10mg10mg£182.00
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Quantity:
TAR-T72029-25mg25mg£258.00
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Quantity:
TAR-T72029-50mg50mg£351.00
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Quantity:
TAR-T72029-100mg100mg£485.00
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Quantity:
TAR-T72029-500mg500mg£946.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity.
CAS:
918523-75-8
Molecular Weight:
237.26
Pathway:
Apoptosis|Cell Cycle/Checkpoint
Purity:
0.9919
SMILES:
O=C(N)C1=CC=CC(=C1)C2=CN=C3NC=CC3=C2
Target:
CDK|Apoptosis

References

Zhang XX, et al. Discovery of a novel oral type ? CDK8 inhibitor against acute myeloid leukemia. Eur J Med Chem. 2023 ; 251:115214.