TargetMol

Carbachol

Product Code:
 
TAR-T0105
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T0105-50mg50mg£111.00
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TAR-T0105-100mg100mg£117.00
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Further Information

Bioactivity:
Carbachol, an analog of acetylcholine, serves as a valuable tool in the investigation of various physiological responses mediated by nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors. These responses include smooth muscle contraction, gut motility, and neuronal signaling. Known for its agonistic properties, Carbachol activates both nAChR and mAChR, with reported Ki values ranging from 10 to 10,000 nM for different receptor types and experimental preparations.
CAS:
51-83-2
Formula:
C6H15ClN2O2
Molecular Weight:
182.65
Pathway:
Neuroscience
Purity:
0.98
SMILES:
[Cl-].O=C(OCC[N+](C)(C)C)N
Target:
AChR

References

Keely SJ, Uribe JM, Barrett KE. Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion. J Biol Chem. 1998 Oct 16;273(42):27111-7. French SJ, et al. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Brain Res Mol Brain Res. 1999 Apr 6;67(1):124-36. Liu X, et al. Opposing muscarinic and nicotinic modulation of hypoglossal motor output to genioglossus muscle in rats in vivo. J Physiol. 2005 Jun 15;565(Pt 3):965-80. Bourgin P, et al. Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation in the rat. Neuroreport. 1995 Feb 15;6(3):532-6. Dharmsathaphorn K, Pandol SJ. Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line. J Clin Invest. 1986 Feb;77(2):348-54.