TargetMol

SC144 hydrochloride

Product Code:
 
TAR-T41260
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SC144 hydrochloride is a first-in-class, orally active small-molecule gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. In addition, SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells [1].
CAS:
917497-70-2
Molecular Weight:
358.76
Purity:
0.98
SMILES:
Cl.O=C(NNC1=NC=2C=C(F)C=CC2N3C=CC=C13)C4=NC=CN=C4