TargetMol

Larazotide

Product Code:
 
TAR-T15711L
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1

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TAR-T15711L-100mg100mgEnquire
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TAR-T15711L-500mg500mgEnquire
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  • Further Information
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Further Information

Bioactivity:
Larazotide is an octapeptide paracellular permeability inhibitor whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease.
CAS:
258818-34-7
Formula:
C32H55N9O10
Molecular Weight:
725.83
Purity:
0.98
SMILES:
C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CN)=O)=O)[C@H](C)C)=O)CC(C)C)=O)C(C)C)=O)CCC(N)=O)(=O)N1[C@H](C(NCC(O)=O)=O)CCC1

Documents

References

Mooney PD, Sanders DS. Commentary: larazotide acetate - an exciting new development for coeliac patients? Aliment Pharmacol Ther. 2013 Feb;37(4):495-6. doi: 10.1111/apt.12183. PubMed PMID: 23336683. Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN; Larazotide Acetate Celiac Disease Study Group. Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther. 2013 Jan;37(2):252-62. doi: 10.1111/apt.12147. Epub 2012 Nov 19. PubMed PMID: 23163616. Leffler DA, Kelly CP, Green PH, Fedorak RN, DiMarino A, Perrow W, Rasmussen H, Wang C, Bercik P, Bachir NM, Murray JA. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology. 2015 Jun;148(7):1311-9.e6. doi: 10.1053/j.gastro.2015.02.008. Epub 2015 Feb 13. PubMed PMID: 25683116; PubMed Central PMCID: PMC4446229. Gopalakrishnan S, Durai M, Kitchens K, Tamiz AP, Somerville R, Ginski M, Paterson BM, Murray JA, Verdu EF, Alkan SS, Pandey NB. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94. doi: 10.1016/j.peptides.2012.02.015. Epub 2012 Feb 27. PubMed PMID: 22401908.