TargetMol

Forasartan

Product Code:
 
TAR-T31845
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T31845-100mg100mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T31845-500mg500mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, leading to vasodilation. In addition, antagonism against AT1 in the adrenal gland prevents angiotensin II-induced adrenal cortical synthesis and aldosterone secretion stimulation.
CAS:
145216-43-9
Molecular Weight:
416.52
Purity:
0.98
SMILES:
N1=NNC(=N1)C=2C=CC=CC2C=3N=CC(=CC3)CN4N=C(N=C4CCCC)CCCC

References

Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role of basally synthesized nitric oxide in modulating the renal vasoconstrictor action of angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259. McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS. Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am J Hypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514. Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065. Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T. Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA expression by high-frequency preganglionic stimulation at the canine cardiac sympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482.