TargetMol

PhTX-433 TFA

Product Code:
 
TAR-T34057
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T34057-100mg100mgEnquire
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TAR-T34057-500mg500mgEnquire
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  • Further Information
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Further Information

Bioactivity:
PhTX-433, also known as Philanthotoxin 433, is a polyamine-containing toxin, which blocks NMDA-gated ion channels; originally isolated from the venom of the wasp Philanthus triangulum.
CAS:
276684-27-6
Molecular Weight:
549.636
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.CCCC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCNCCCN

Documents

References

Franzyk H, Grzeskowiak JW, Tikhonov DB, Jaroszewski JW, Mellor IR. The effects of conformational constraints in the polyamine moiety of philanthotoxins on AMPAR inhibition. ChemMedChem. 2014 Aug;9(8):1725-31. doi: 10.1002/cmdc.201402109. Epub 2014 Jul 8. PubMed PMID: 25044789. Kachel HS, Patel RN, Franzyk H, Mellor IR. Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition. Sci Rep. 2016 Nov 30;6:38116. doi: 10.1038/srep38116. PubMed PMID: 27901080; PubMed Central PMCID: PMC5128878. McGee TP, Bats C, Farrant M, Cull-Candy SG. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci. 2015 Dec 9;35(49):16171-9. doi: 10.1523/JNEUROSCI.2152-15.2015. PubMed PMID: 26658868; PubMed Central PMCID: PMC4682783. Park P, Sanderson TM, Amici M, Choi SL, Bortolotto ZA, Zhuo M, Kaang BK, Collingridge GL. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci. 2016 Jan 13;36(2):622-31. doi: 10.1523/JNEUROSCI.3625-15.2016. PubMed PMID: 26758849; PubMed Central PMCID: PMC4710778.