LIGHT, Soluble (human) (rec.)
| Code | Size | Price |
|---|
| AG-40B-0009-C010 | 10 ug | £125.00 |
Quantity:
| AG-40B-0009-3010 | 3 x 10 ug | £240.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
HVEML; Tumor Necrosis Factor Ligand Superfamily Member 14; TNFSF14; CD258
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Human LIGHT (aa 89-240) is fused at the N-terminus to a FLAG®-tag. Source: CHO cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse LTbetaR and human HVEM and DcR3. Purity: >95% (SDS-PAGE). LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-kappaB, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Molecular Weight:
~25kDa (SDS-PAGE)
NCBI, Uniprot Number:
O43557
Package Type:
Plastic Vial
Product Description:
LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-kappaB, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Purity:
>95% (SDS-PAGE)
Sequence:
Human LIGHT (aa 89-240) is fused at the N-terminus to a FLAG®-tag.
Source / Host:
CHO cells
Specificity:
Binds to human and mouse LTbetaR and human HVEM and DcR3.
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-kappaB: M. Lubrano di Ricco, et al.; Eur. J. Immunol. 50, 972 (2020)