HVEM (CD270; TNFRSF14) is a molecular switch that acts both as an immune system stimulator and as an inhibitor. It is expressed in T cells, B cells, natural killer cells, dendritic cells and endothelial cells. LIGHT is an immune stimulator that contributes to dendritic cell maturation and T cell expansion. The immune suppressor BTLA functions in opposition to LIGHT in the suppression of naïve T cell expansion and induction of Treg cells. CD160 acts as an immune suppressor through its interactions with HVEM. The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions that function in both immune stimulation and suppression and which is a potential therapeutic target for the treatment of autoimmune diseases and allergies and controlling antitumour responses.
LIT: Identification of CD112R as a novel checkpoint for human T cells: Y. Zhu, et al.; J. Exp. Med. 213, 167 (2016) • Cosignaling molecules around LIGHT-HVEMBTLA: from immune activation to therapeutic targeting: C. Pasero, et al.; Curr. Mol. Med. 9, 911 (2009) • HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation: M.L. del Rio, et al.; J. Leukoc. Biol. 87, 223 (2010)
Biologically Active HVEM, BTLA, CD160 and LIGHT Proteins
See all Biologically Active HVEM Proteins here.
See all Biologically Active BTLA Proteins here.
See all Biologically Active CD160 Proteins here.
See all Biologically Active LIGHT Proteins here.
VALIDATED Antibodies for BTLA and HVEM Research
See all VALIDATED Antibodies for BTLA Research by AdipoGen Life Sciences here.
See all VALIDATED Antibodies for BTLA Research by Ancell here.
See all VALIDATED Antibodies for HVEM Research here.
Originally posted on adipogen.com/hvem-btla-light-cd160-network/
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