BAFF Soluble (human) Matched Pair Detection Set
| Code | Size | Price |
|---|
| AG-46B-0001-KI01 | 1 Set | £570.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
Blue Ice
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
BlyS; B Cell Activating Factor
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
Avoid freeze/thaw cycles.
Kit Contains:
1 vial standard protein (5µg) (lyophilized) [STD] | 1 vial coating antibody (120µl) [COAT] | 1 vial detection antibody (60µl) [DET] | 1 vial streptavidin-HRP (10µg) (lyophilized) [STREP]
Long Description:
Matched Pair Detection Set. Detects human BAFF. Does not detect mouse BAFF. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 16 to 1000pg/ml. Sensitivity: 16pg/ml. BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren?s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
NCBI, Uniprot Number:
Q5H8V1
Package Type:
Box
Product Description:
BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren?s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Range:
16 to 1000pg/ml
Sample Type:
Cell Culture Supernatant, Plasma, Serum
Sensitivity:
16pg/ml
Specificity:
Detects human BAFF. Does not detect mouse BAFF.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Elevated serum BAFF levels in patients with autoimmunity and lymphoproliferation: A. Janda, et al.; Scand. J. Immunol.74, 518 (2011) | HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes: A.M. Gomez, et al.; J. Immunol. 194, 2300 (2015) | HIV-1-mediated BAFF secretion in macrophages does not require endosomal TLRs, type-I IFN, and Nef, but depends on the cellular phenotype status: A.M. Gomez, et al.; J. Immunol. 196, 3806 (2016)