SIN-1 chloride
| Code | Size | Price |
|---|
| AG-CR1-0027-M010 | 10 mg | £40.00 |
Quantity:
| AG-CR1-0027-M050 | 50 mg | £110.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
3-Morpholinosydnonimine; Linsidomine
Appearance:
White to off-white solid.
CAS:
16142-27-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302
InChi:
InChI=1S/C6H11N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5H,1-4,7H2;1H/q+1;/p-1
InChiKey:
ZRFWHHCXSSACAW-UHFFFAOYSA-M
Long Description:
Chemical. CAS: 16142-27-1. Formula: C6H11ClN4O2. MW: 206.6. Nitric oxide (NO) donor. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite. Platelet aggregation inhibitor. Guanylyl cyclase activator. Cytotoxic. Positive ionotropic. Vasodilator.
MDL:
MFCD00221615
Molecular Formula:
C6H11ClN4O2
Molecular Weight:
206.6
Other data:
Use freshly prepared solutions.
Package Type:
Vial
Precautions:
P264, P270, P301, P312, P330
Product Description:
Nitric oxide (NO) donor [1]. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite [1]. Platelet aggregation inhibitor [2, 3]. Guanylyl cyclase activator [2, 3]. Cytotoxic [4]. Positive ionotropic [5]. Vasodilator [6].
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
NC1=C[N+](N2CCOCC2)=NO1.[Cl-]
Solubility Chemicals:
Soluble in 100% ethanol, water or DMSO (> 5 mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Nitric Oxide Donors
UNSPSC Number:
41116113
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide: N. Hogg et al.; Biochem. J. 281|419 (1992) | Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites: M. Nishikawa et al.; J. Phar.macol. Exp. Ther. 220, 183 (1982) | Synergistic platelet antiaggregatory effects of the adenylate cyclase activator iloprost and the guanylate cyclase activating agent SIN-1 in vivo: M. Spiecker, et al.; Thromb. Res. 70, 405 (1993) | SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium: K. Konishi, et al.; Nitric Oxide 20, 270 (2009) | cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes: M.J. Kohr, et al.; J. Mol. Cell. Cardiology 48, 645 (2010) | Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists: W. Schulz & G. Kober; Basic Res. Cardiol. 86, 233 (1991) | Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages: Y. Zhang & O.J. Igwe; Int. Pharmacol. 54, 226 (2017) | Exogenous oxidants activate nuclear factor kappa B through Toll-like receptor 4 stimulation to maintain inflammatory phenotype in macrophage: Y. Zhang & O.J. Igwe; Biochem. Pharmacol. ahead of print (2017) | Role of nitric oxide on zymosan-induced inhibition of crop emptying in chicks: M. Takahashi, et al.; Comp. Biochem. Physiol. 261, 111057 (2021)
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