LY-294002
| Code | Size | Price |
|---|
| AG-CR1-0108-M001 | 1 mg | £35.00 |
Quantity:
| AG-CR1-0108-M005 | 5 mg | £50.00 |
Quantity:
| AG-CR1-0108-M025 | 25 mg | £130.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Appearance:
White to off-white crystalline solid.
CAS:
154447-36-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChiKey:
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 154447-36-6. Formula: C19H17NO3. MW: 307.4. Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
MDL:
MFCD00270881
Molecular Formula:
C19H17NO3
Molecular Weight:
307.4
Package Type:
Vial
Product Description:
Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
Purity:
>99% (NMR)
SMILES:
O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCOCC1
Solubility Chemicals:
Soluble in DMSO, 100% ethanol or methanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002): C.J. Vlahos, et al.; J. Biol. Chem. 269, 5241 (1994) | Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase: C.J. Vlahos, et al.; J. Immunol. 154, 2413 (1995) | Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005) | LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway: T.W. Poh & S. Pervaiz; Cancer Res. 65, 6264 (2005) | LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance: M. Baranc?k, et al.; Eur. J. Pharm. Sci. 29, 426 (2006) | A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder: F.J. Tamarkin, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 373, 349 (2006) | Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 15, 5837 (2007) | The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains: A. Dittmann, et al.; ACS Chem. Biol. 9, 495 (2014)
Related Products
| Product Name | Product Code | Supplier | Wortmannin | AG-CN2-0023 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|