Ancell

anti-TCR C beta 1 (human), mAb (Jovi-1) (R-PE)

Product Code:
 
ANC-101-050
Product Group:
 
Primary Antibodies
Supplier:
 
Ancell
Antibody Isotype:
 
Mouse IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Jovi-1
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
BI
Storage:
 
+4deg;C
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ANC-101-050-120tests120 tests£580.00
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Further Information

Alternate Names/Synonyms:
TCRB; T Cell Receptor beta Locus; TRBC1
EClass:
32160000
Form (Short):
liquid
Formulation:
50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative).
Handling Advice:
Do not freeze.
Immunogen:
Human HA1.7 TCR beta chain expressed on transgenic mouse cells.
Labels - Conjugates:
R-PE
Long Description:
Monoclonal Antibody. Isotype: Mouse IgG2a. Clone: Jovi-1. Applications: FACS. 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR?s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells.
Package Type:
Plastic Vial
Product Description:
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR?s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells. This specific TRBC1 antibody has been described to be useful in a simplified immunophenotypic assessment of T cell clonality.
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes human Cbeta1 TCR gene product (TRBC1) and reacts with 50-75% of T cells in normal human blood. Does not bind to TCR Cbeta2 (TRBC2).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibody Conjugates
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.

References

Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice: J.L. Viney, et al.; Hybridoma 11, 701 (1992) | T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases: A. Weiss, et al.; Cell 73, 209 (1993) | Targeting the T cell receptor beta-chain constant region for immunotherapy of T cell malignancies: P.M. Maciocia, et al.; Nat. Med. 23, 1416 (2017) | Single Antibody Detection of T-Cell Receptor alphabeta Clonality by Flow Cytometry Rapidly Identifies Mature T-Cell Neoplasms and Monotypic Small CD8-Positive Subsets of Uncertain Significance: M. Shi, et al.; Cytometry B Clin. Cytom. 98, 99 (2020)