S14161
| Code | Size | Price |
|---|
| AG-CR1-3516-M001 | 1 mg | £65.00 |
Quantity:
| AG-CR1-3516-M005 | 5 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran; 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene
Appearance:
Yellow solid.
CAS:
883046-50-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
InChiKey:
FZXDHIUPNWOMT-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 883046-50-2. Formula: C17H14FNO4. MW: 315.3. Potent antileukemia and antimyeloma compound. Apoptosis inducer. Delays tumor growth. Cyclin D2 promoter transactivation inhibitor. Inhibitor of pan-Class I PI3K isoforms.
MDL:
MFCD00112055
Molecular Formula:
C17H14FNO4
Molecular Weight:
315.3
Package Type:
Vial
Product Description:
Potent antileukemia and antimyeloma compound [1]. Apoptosis inducer [1]. Delays tumor growth [1]. Cyclin D2 promoter transactivation inhibitor [1]. Inhibitor of pan-Class I PI3K isoforms [1,2].
Purity:
>99% (NMR)
SMILES:
CCOC1=C2OC(C3=CC=C(F)C=C3)C(=CC2=CC=C1)[N+]([O-])=O
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway: X. Mao, et al.; Blood 117, 1986 (2011) | Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization: K. Han, et al.; J. Hematol. Oncol. 7, 1756 (2014)
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