AdipoGen Life Sciences

Irisin (rec.) (CHO)

Product Code:
 
AG-40B-0136
Product Group:
 
Recombinant Proteins
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Shipping:
 
Blue Ice
Storage:
 
-20°C
 

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CodeSizePrice
AG-40B-0136-C01010 ug£310.00
Quantity:
AG-40B-0136-30103 x 10 ug£610.00
Quantity:
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Further Information

Alternate Names/Synonyms:
Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)
Biological Activity:
Activates brown adipocyte markers Ucp1 and Cidec in murine subcutaneous adipocytes at 10ng/ml [Lit. 1].
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Irisin (human, aa 32-143 /mouse, aa 29-140) is FLAG®-tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human. Source: CHO cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
Molecular Weight:
~26kDa
NCBI, Uniprot Number:
Q8NAU1
Package Type:
Plastic Vial
Product Description:
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Neuroprotectant in Alzheimer's disease.
Purity:
>95% (SDS-PAGE)
Sequence:
Irisin (human, aa 32-143 /mouse, aa 29-140) is FLAG®-tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human.
Source / Host:
CHO cells
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

References

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice: A. Rodriguez, et al.; Int. J. Obes. 39, 397 (2015) | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer?s models: M.V. Lourenko, et al.; Nat. Med. 25, 165 (2019) | Irisin levels in genetic and essential obesity: clues for a potential dual role: S. Mai, et al.; Nature Sci. Rep. 10, 1020 (2020) | Exercise hormone irisin is a critical regulator of cognitive function: M.R. Islam, et al.; Nat. Metab. 3, 1058 (2021)