ProSci

NOD4 Antibody

Product Code:
 
PSI-5951
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of NOD4 in EL4 cell lysate with NOD4 antibody at 1 μg/mL.
2 / 3
Immunocytochemistry of NOD4 in HeLa cells with NOD4 antibody at 10 μg/mL.
3 / 3
Immunofluorescence of NOD4 in HeLa cells with NOD4 antibody at 20 μg/mL.
❮❯

Western blot analysis of NOD4 in EL4 cell lysate with NOD4 antibody at 1 μg/mL.
Immunocytochemistry of NOD4 in HeLa cells with NOD4 antibody at 10 μg/mL.
Immunofluorescence of NOD4 in HeLa cells with NOD4 antibody at 20 μg/mL.

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CodeSizePrice
PSI-5951-0.02mg0.02mg£150.00
Quantity:
PSI-5951-0.1mg0.1mg£449.00
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Further Information

Additional Names:
NOD4 Antibody: NOD4, NOD27, CLR16.1, NOD4, Protein NLRC5, Nucleotide-binding oligomerization domain protein 27
Application Note:
NOD4 antibody can be used for detection of NOD4 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NOD4 Antibody: NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-κB and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
Background References:
  • Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci. 2006; 1072:19-27.
  • Benko S, Magalhaes JG, Philpott DJ, et al. NLRC5 limits the activation of inflammatory pathways. J. Immunol. 2010; 185:1681-91.
  • Meissner TB, Li A, Biswas A, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. USA 2010; 107:13794-9.
  • Cui J, Zhu L, Xia X, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 2010; 141:483-96.
Buffer:
NOD4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NOD4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NOD4.

The immunogen is located within amino acids 20 - 70 of NOD4.
NCBI Gene ID #:
84166
NCBI Official Name:
NLR family, CARD domain containing 5
NCBI Official Symbol:
NLRC5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
205 kDa
Protein Accession #:
NP_115582
Protein GI Number:
116268109
Purification:
NOD4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
NOD4 antibody is predicted to not cross-react with other members of the NOD family of proteins.
Swissprot #:
Q86WI3
User NOte:
Optimal dilutions for each application to be determined by the researcher.