ProSci

SPATA18 Antibody

Product Code:
 
PSI-6615
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Chicken
Antibody Isotype:
 
IgY
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
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Western blot analysis of SPATA18 in rat lung tissue lysate with SPATA18 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide
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Western blot analysis of SPATA18 in rat lung tissue lysate with SPATA18 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

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CodeSizePrice
PSI-6615-0.02mg0.02mg£150.00
Quantity:
PSI-6615-0.1mg0.1mg£449.00
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Further Information

Additional Names:
SPATA18 Antibody: Mieap, SPETEX1, MIEAP, Mitochondria-eating protein, Spermatogenesis-associated protein 18
Application Note:
SPATA18 antibody can be used for detection of SPATA18 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
SPATA18 Antibody: SPATA18, also known as SPETEX-1, was initially identified as a cytoplasmic protein of elongate spermatids that is thought to be involved in differentiation process of elongate spermatids to mature spermatozoa. Recent experiments have shown that SPATA18 is a transcriptional target of p53 and p63. It has also been suggested to play a role in mitochondria quality control by inducing intramitochondrial lysosome-like organella that eliminate oxidized mitochondrial proteins.
Background References:
  • Iida H, Ichinose J, Kaneko T, et al. Complementary DNA cloning of rat spetex-1, a spermatid-expressing gene-1, encoding a 63 kDa cytoplasmic protein of elongate spermatids. Mol. Reprod. Dev. 2004; 68:385-93.
  • Bornstein C, Brosh R, Molchadsky A, et al. SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol. Cell Biol. 2011; 31:1679-89
  • Miyamoto Y, Kitamura N, Nakamura Y, et al. Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. PLoS One 2011; 6:e16054.
Buffer:
SPATA18 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SPATA18 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SPATA18.

The immunogen is located within amino acids 90 - 140 of SPATA18.
NCBI Gene ID #:
132671
NCBI Official Name:
spermatogenesis associated 18
NCBI Official Symbol:
SPATA18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_660306
Protein GI Number:
21687119
Purification:
SPATA18 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
At least three isoforms of SPATA18 are known to exist; this antibody will detect the two longest isoforms. SPATA18 antibody is predicted to not cross-react with other SPATA family members.
Swissprot #:
Q8TC71
User NOte:
Optimal dilutions for each application to be determined by the researcher.