ProSci

BOK Antibody

Product Code:
 
PSI-3357
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
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Immunohistochemistry of BOK in human brain tissue with BOK antibody at 5 μg/mL.
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Immunohistochemistry of BOK in human brain tissue with BOK antibody at 5 μg/mL.

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CodeSizePrice
PSI-3357-0.02mg0.02mg£150.00
Quantity:
PSI-3357-0.1mg0.1mg£449.00
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Further Information

Additional Names:
BOK Antibody: BOKL, BCL2L9, Bcl-2-related ovarian killer protein, Bcl-2-like protein 9, hBOK
Application Note:
BOK antibody can be used for detection of BOK by immunohistochemistry at 5 μg/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
BOK Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. BOK, a pro-apoptotic Bcl-2 family member, was initially identified in the ovary, and was found to interact with other Bcl-2 family members such as Mcl-1 and Bfl-1. BOK expression is high during early placental development, suggesting that it may also play a role in regulating trophoblast cell proliferation.
Background References:
  • Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
  • Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
  • Hsu SY, Kaipia A, McGee E, et al. bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. USA 1997; 94:12401-6
  • Soleymanlou N, Wu Y, Wang JX, et al. A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. Cell Death Differ. 2005; 12:441-52.
Buffer:
BOK Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%), Chicken: (81%)
Immunogen:
BOK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BOK.

The immunogen is located within the first 50 amino acids of BOK.
NCBI Gene ID #:
666
NCBI Official Name:
BCL2-related ovarian killer
NCBI Official Symbol:
BOK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAH06203
Protein GI Number:
14210524
Purification:
BOK Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
At least three isoforms of BOK are known to exist; this antibody will not detect the smallest isoform. BOK antibody is predicted to not cross-react with other Bcl-2 protein family members
Swissprot #:
Q9UMX3
User NOte:
Optimal dilutions for each application to be determined by the researcher.