ProSci

RRAS2 Antibody

Product Code:
 
PSI-7249
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
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Western blot analysis of RRAS2 in Jurkat cell lysate with RRAS2 antibody at (A) 1 and (B) 2 μg/mL
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Western blot analysis of RRAS2 in Jurkat cell lysate with RRAS2 antibody at (A) 1 and (B) 2 μg/mL

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CodeSizePrice
PSI-7249-0.02mg0.02mg£150.00
Quantity:
PSI-7249-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
RRAS2 Antibody: TC21, TC21, Ras-related protein R-Ras2, Ras-like protein TC21
Application Note:
RRAS2 antibody can be used for detection of RRAS2 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55?60%. RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.
Background References:
  • Ehrhardt A, Ehrhardt GR, Guo X, et al. Ras and relatives--job sharing and networking keep an old family together. Exp. Hematol. 2002; 30:1089-106.
  • Lowe DG, Capon DJ, Delwart E, et al. Structure of the human and murine R-Ras genes, novel genes closely related to Ras proto-oncogenes. Cell 1987; 48:137-46
  • Drivas GT, Shih A, Coutavas E, et al. Characterization of four novel Ras-like genes expressed in a human teratocarcinoma cell line. Mol. Cell. Biol. 1990;10:1793-8.
  • Luo H, Hao X, Ge C, et al. TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma. Int. J. Oncol. 2010; 37:853-9
Buffer:
RRAS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal RRAS2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human RRAS2.

The immunogen is located within the last 50 amino acids of RRAS2.
NCBI Gene ID #:
22800
NCBI Official Name:
related RAS viral (r-ras) oncogene homolog 2
NCBI Official Symbol:
RRAS2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Protein Accession #:
NP_036382
Protein GI Number:
21361416
Purification:
RRAS2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
Two isoforms of RRAS2 exists as a result of alternative splicing event.
Swissprot #:
P62070
User NOte:
Optimal dilutions for each application to be determined by the researcher.