ProSci

NR1I2 Antibody

Product Code:
 
PSI-25-312
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store NR1I2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
1 / 3
Antibody used in IHC on Human Small Intestine at 5.0 ug/ml.
2 / 3
3 / 3
Antibody used in WB on Hum. Fetal Muscle at 1 ug/ml.
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Antibody used in IHC on Human Small Intestine at 5.0 ug/ml.
Antibody used in WB on Hum. Fetal Muscle at 1 ug/ml.

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PSI-25-312-100ul100ul£662.00
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This product comes from: United States.
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Further Information

Additional Names:
NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Application Note:
NR1I2 antibody can be used for detection of NR1I2 by ELISA at 1:1562500. NR1I2 antibody can be used for detection of NR1I2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Background References:
  • Hesselink, D.A., (2008) Pharmacogenomics 9 (6), 783-789.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1I2.
NCBI Gene ID #:
8856
NCBI Official Name:
nuclear receptor subfamily 1, group I, member 2
NCBI Official Symbol:
NR1I2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
NP_003880
Protein GI Number:
34398348
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
Transcription ,Cancer ,Signal Transduction
Swissprot #:
O75469
User NOte:
Optimal dilutions for each application to be determined by the researcher.