Further Information
HD8, WTS, RPD3, CDA07, CDLS5, MRXS6, HDACL1, MAPKAPK1A, RSK1, HD8, HDA8
Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
- Lee H, et al. (2004) Mol Cell Biol. 24 (2): 765-773.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
HDAC8 (Phospho-Ser39) antibody was raised against a peptide sequence around phosphorylation site of serine 39 (R-A-S (p) -M-V) derived from Human HDAC8.
Phospho-Specific
55869
histone deacetylase 8
HDAC8
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
NP_001159890.1
262073088
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific,Cell Cycle
This antibody detects endogenous level of HDAC8 only when phosphorylated at serine 39.
Q9BY41