Further Information
HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, RNF1, HD4/HD5/HD9
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
- Cress, W. D. and Seto, E. (2000) J Cell Physiol 184, 1-16. Vigushin, D. M. and Coombes, R. C. (2004) Curr. Cancer Drug Targets 4, 205-218. Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703. Thiagalingam, S. et al. (2003) Ann. N. Y. Acad. Sci. 983, 84-100.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
HDAC4/HDAC5/HDAC9 (Ab-246/259/220) antibody was raised against a peptide sequence around aa.244~248/257~261/218~222 (T-A-S-E-P) derived from Human HDAC4/HDAC5/HDAC9.
9759 / 10014 / 9734
histone deacetylase 4 / histone deacetylase 5 / histone deacetylase 9
HDAC4 HDAC5 HDAC9
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
140, 124 kDa
NP_006028.2 / NP_001015053.1 / NP_055522.1
153085395 / 62750349 / 7662280
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Cell Cycle
This antibody detects endogenous level of total HDAC4/HDAC5/HDAC9 protein.
P56524 Q9UQL6 Q9UKV0