Further Information
TCF, HNF4, MODY, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha, HNRPA1, TCF, HNF4A
Western Blot: 1:1000
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.
- Kritis A. A, et al. Gene 173:275-280 (1996) Drewes T, et al. Mol. Cell. Biol. 16:925-931 (1996) Yamagata K, et al. Nature 384:458-460 (1996) Tanaka T, et al. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
HNF4a (Phospho-Ser304) antibody was raised against a peptide sequence around phosphorylation site of serine 304 (L-R-S (p) -Q-V) derived from Human HNF4α.
Phospho-Specific
3172
hepatocyte nuclear factor 4, alpha
HNF4A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
NP_000448.3
31077205
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific
This antibody detects endogenous level of HNF4α only when phosphorylated at serine 304.
P41235