Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
CANDF7, ISGF-3, STAT91, Osf2
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-γ-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
- Yuan ZM, et al. (1999) Nature. 399 (6738): 814-817. Schindler C, et al. (1992) Proc. Natl. Acad. Sci. U. S. A 89:7836-7839. Strausberg R. L (2002) . Proc. Natl. Acad. Sci. U. S. A. 99:16899-16903. Quelle F. W., (1995) J. Biol. Chem. 270:20775-20780.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
STAT1 (Ab-727) antibody was raised against a peptide sequence around aa.725~729 (P-M-S-P-E) derived from Human STAT1.
6772
signal transducer and activator of transcription 1, 91kDa
STAT1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
91 kDa
NP_009330.1
6274552
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Apoptosis,Cancer
This antibody detects endogenous level of total STAT1 protein.
P42224