ProSci

Stat2 Antibody

Product Code:
 
PSI-79-508
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 1
Western blot analysis of lysed extracts from HeLa cells untreated or treated with IFN-α using Stat2 (phospho-Tyr690).
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Western blot analysis of lysed extracts from HeLa cells untreated or treated with IFN-α using Stat2 (phospho-Tyr690).

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PSI-79-508-0.1mg0.1mg£488.00
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Further Information

Additional Names:
P113, ISGF-3, STAT113, MAPKAPK1A, RSK1, P113, MGC59816
Application Note:
Western Blot: 1:1000
Background:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
Background References:
  • Fu X. Y, et al. Proc. Natl. Acad. Sci. U. S. A. 89:7840-7843 (1992) Yan R, et al. Nucleic Acids Res. 23:459-463 (1995) Fu X. Y. Cell 70:323-335 (1992) Sugiyama T, et al. FEBS Lett. 381:191-194 (1996)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Stat2 (phospho-Tyr690) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y (p) -L-K) derived from Human Stat2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
6773
NCBI Official Name:
signal transducer and activator of transcription 2, 113kDa
NCBI Official Symbol:
STAT2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
NP_005410.1
Protein GI Number:
4885615
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.
Swissprot #:
P52630