Antibody Clonality:
Polyclonal
Antibody Clone:
242247251
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
WWC1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
WW and C2 domain containing 1, HBEBP3, HBEBP36, KIBRA, MEMRYQTL
WWC1 antibody can be used for detection of WWC1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
The WW and C2 domain containing 1 (WWC1) protein, also known as KIBRA, possesses two WW domains and an internal C2-like domain (1). WWC1 was originally identified as a memory performance-associated protein in humans (2) and has recently been shown to be a novel regulator of the Hippo pathway (3). WWC1 is phosphorylated by the mitotic kinases Aurora-A and ?B (4), and in turn activates the Aurora kinases and is required for precise chromosome alignment during mitosis (5).
- Kremerskothen J, Plaas C, Buther K, et al. Characterization of KIBRA, a novel WW domain-containing protein. Biochem. Biophys. Res. Commun. 2003; 300:862-7.
- Papassotiropoulos A, Stephan DA, Huentelman MJ, et al. Common Kibra alleles are associated with human memory performance. Science 2006; 314:475-8.
- Genevet A, Wehr MC, Brain R, et al. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev. Cell 2010; 18:309-16.
- Xiao L, Chen Y, Ji M, et al. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J. Biol. Chem. 2011; 286:36304-15.
WWC1 antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
WWC1 antibody was raised against an 18 amino acid peptide near the amino terminus of human WWC1.
The immunogen is located within amino acids 60 - 110 of WWC1.
23286
WW and C2 domain containing 1
WWC1
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 123 kDa
Observed: 110 kDa
NP_001155133
242247251
WWC1 antibody is affinity chromatography purified via peptide column.
Homeostasis,Neuroscience
WWC1 antibody is human, mouse and rat reactive. At least three isoforms of WWC1 are known to exist; this antibody will detect all three isoforms.
Q8IX03
Optimal dilutions for each application to be determined by the researcher.