ProSci

Osteonectin Recombinant Protein

Product Code:
 
PSI-40-571
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Osteonectin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Osteonectin stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any prote
 

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CodeSizePrice
PSI-40-571-0.01mg0.01mg£300.00
Quantity:
PSI-40-571-0.05mg0.05mg£428.00
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
ON, ON, SPARC, Basement-membrane protein 40, BM-40
Background:
SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains; an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Recombinant human SPARC/Osteonectin is a glycoprotein containing 286 amino acids that migrates at an apparent MW of 43.7 kDa by SDS-PAGE analysis due to the effect of glycosylation.
Biological Activity:
Biological activity was determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3 cells using a concentration of IC50 0.5-0.7 μg/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
6678
NCBI Official Name:
secreted protein, acidic, cysteine-rich (osteonectin)
NCBI Official Symbol:
SPARC
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003109.1
Protein GI Number:
4507171
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
CHO cells
Swissprot #:
P09486

Documents