ProSci

sCD30 Ligand Recombinant Protein

Product Code:
 
PSI-40-569
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized sCD30 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted sCD30 Ligand stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pro
 

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CodeSizePrice
PSI-40-569-0.01mg0.01mg£300.00
Quantity:
PSI-40-569-0.05mg0.05mg£428.00
Quantity:
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Further Information

Additional Names:
CD153, CD30L, CD30LG, Tumor necrosis factor ligand superfamily member 8, CD30 ligand, CD30-L
Background:
CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein protein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-KappaB. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, or cell division. Certain diseases, including Hodgkins?s lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain. Recombinant human soluble CD30L (sCD30L) is a 188 amino acid polypeptide corresponding to the extracellular domain, and contains an 8 residue N-terminal His -Tag.
Biological Activity:
Biological activity was determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/mL. Note: Results may vary with PBMC donors. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
944
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 8
NCBI Official Symbol:
TNFSF8
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001235.1
Protein GI Number:
4507607
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
CHO cells
Swissprot #:
P32971

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