ProSci

MMP-1 Recombinant Protein

Product Code:
 
PSI-40-143
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized MMP-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MMP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
 

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CodeSizePrice
PSI-40-143-0.002mg0.002mg£300.00
Quantity:
PSI-40-143-0.01mg0.01mg£428.00
Quantity:
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Further Information

Additional Names:
CLG, CLGN, CLG, Interstitial collagenase, Fibroblast collagenase, MMP-1
Background:
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant human MMP-1 is a 42.7 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain which is involved in substrate specificity and in binding TIMP-1.
Biological Activity:
MMP - 1 activity was measured by its ability to cleave a chromogenic peptide MMP - 1 substrate at room temperature. At an MMP - 1 concentration of 2.5 μg/mL, 50% cleavage was achieved at an incubation time of approximately 25 minutes
NCBI Gene ID #:
4312
NCBI Official Name:
matrix metallopeptidase 1 (interstitial collagenase)
NCBI Official Symbol:
MMP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001139410.1
Protein GI Number:
225543094
Purity:
Greater than 90% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P03956

Documents