ProSci

MMP-3 Recombinant Protein

Product Code:
 
PSI-40-525
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized MMP-3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MMP-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
 

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CodeSizePrice
PSI-40-525-0.002mg0.002mg£300.00
Quantity:
PSI-40-525-0.01mg0.01mg£428.00
Quantity:
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Further Information

Additional Names:
SL-1, STMY, STR1, CHDS6, MMP-3, STMY1, Stromelysin-1, Matrix metalloproteinase-3, SL-1
Background:
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).
Biological Activity:
MMP-3 activity was measured by its ability to cleave a chromogenic peptide MMP-3 substrate at room temperature. At a MMP-3 concentration of 2.5 μg/mL, 50% cleavage was achieved at an incubation time of approximately 75 minutes.
NCBI Gene ID #:
4314
NCBI Official Name:
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
NCBI Official Symbol:
MMP3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002413.1
Protein GI Number:
4505217
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P08254

Documents