ProSci

TSLP Recombinant Protein

Product Code:
 
PSI-40-294
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized TSLP recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TSLP is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
 

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CodeSizePrice
PSI-40-294-0.002mg0.002mg£300.00
Quantity:
PSI-40-294-0.01mg0.01mg£428.00
Quantity:
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
Thymic stromal lymphopoietin
Background:
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed na?ve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
NCBI Gene ID #:
85480
NCBI Official Name:
thymic stromal lymphopoietin
NCBI Official Symbol:
TSLP
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_149024.1
Protein GI Number:
14719428
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q969D9

Documents