ProSci

MIA Recombinant Protein

Product Code:
 
PSI-40-226
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized MIA recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MIA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing
 

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CodeSizePrice
PSI-40-226-0.005mg0.005mg£300.00
Quantity:
PSI-40-226-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
CD-RAP, Melanoma-derived growth regulatory protein, Melanoma inhibitory activity protein
Background:
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.
Biological Activity:
The ED50 was determined by the dose - dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4 - 6 μg/mL.
NCBI Gene ID #:
8190
NCBI Official Name:
melanoma inhibitory activity
NCBI Official Symbol:
MIA
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001189482.1
Protein GI Number:
321400133
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q16674

Documents