ProSci

Nanog-TAT Recombinant Protein

Product Code:
 
PSI-40-526
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Nanog-TAT recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Nanog-TAT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protei
 

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CodeSizePrice
PSI-40-526-0.005mg0.005mg£300.00
Quantity:
PSI-40-526-0.02mg0.02mg£428.00
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Further Information

Additional Names:
PN8, NANOG, NANOGP1, Putative homeobox protein NANOGP8
Background:
Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of Nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of Nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, which helps maintain pluripotency and self renewal via a STAT3 independent pathway. The introduction of Nanog, along with Sox2, Oct4, Lin28, into primary human fibroblasts was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology and gene expression. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors into primary as well as transformed cells. Recombinant human Nanog-TAT is a 36.1 kDa protein, which is synthesized as a 304 amino acid polypeptide plus a 13- residue C-terminal TAT peptide.
Biological Activity:
Endotoxin level is less than 0.1 ng per ug (1EU/μg).
NCBI Gene ID #:
388112
NCBI Official Name:
Nanog homeobox pseudogene 8
NCBI Official Symbol:
NANOGP8
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
Q6NSW7
Protein GI Number:
74762336
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q6NSW7

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