ProSci

PDGF-CC Recombinant Protein

Product Code:
 
PSI-40-146
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized PDGF-CC recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted PDGF-CC is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
 

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CodeSizePrice
PSI-40-146-0.005mg0.005mg£300.00
Quantity:
PSI-40-146-0.02mg0.02mg£428.00
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Further Information

Additional Names:
SCDGF, FALLOTEIN, SCDGF, UNQ174/PRO200, Platelet-derived growth factor C, Fallotein, PDGF-C
Background:
The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.
Biological Activity:
Biological activity was determined by the dose - dependent stimulation of the proliferation of Balb/c 3T3 cells. The expectedThe ED50 for this effect is 15 - 20 ng/mL.
NCBI Gene ID #:
56034
NCBI Official Name:
platelet derived growth factor C
NCBI Official Symbol:
PDGFC
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_057289.1
Protein GI Number:
9994187
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q9NRA1

Documents