ProSci

IL-17A Recombinant Protein

Product Code:
 
PSI-40-263
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized IL-17A recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-17A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
 

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CodeSizePrice
PSI-40-263-0.005mg0.005mg£300.00
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PSI-40-263-0.025mg0.025mg£428.00
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Further Information

Additional Names:
IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8
Background:
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
Biological Activity:
Assay #1: Measured by its ability to induce IL-6 production by NHDF cells, using a concentration range of 0.5-1.5 ng/ml.

Assay #2: Measured by its ability to induce GRO-alpha production by HT-29 cells, using a concentration range of 0.5-5.0 ng/ml.
NCBI Gene ID #:
3605
NCBI Official Name:
interleukin 17A
NCBI Official Symbol:
IL17A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002181.1
Protein GI Number:
4504651
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q16552

Documents