ProSci

IL-1 Receptor Agonist Recombinant Protein

Product Code:
 
PSI-40-242
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized IL-1 Receptor Agonist recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-1 Receptor Agonist is stable for at least 3 months when stored in working aliquots with a carrier protein at -20&d
 

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CodeSizePrice
PSI-40-242-0.02mg0.02mg£300.00
Quantity:
PSI-40-242-0.1mg0.1mg£428.00
Quantity:
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This product comes from: United States.
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Further Information

Additional Names:
DIRA, IRAP, IL1F3, IL1RA, MVCD4, IL-1RN, IL-1ra, IL-1ra3, ICIL-1RA, Interleukin-1 receptor antagonist protein
Background:
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
Biological Activity:
Biological activity was determined by its ability to inhibit the IL - 1alpha stimulation of murine D10S cell. The expected ED50is 20 - 40 ng/mL in the presence of 50 pg/mL of IL - 1alpha.
NCBI Gene ID #:
3557
NCBI Official Name:
interleukin 1 receptor antagonist
NCBI Official Symbol:
IL1RN
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000568.1
Protein GI Number:
10835147
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P18510

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