ProSci

VEGF-D Recombinant Protein

Product Code:
 
PSI-40-166
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized VEGF-D recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted VEGF-D is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
 

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CodeSizePrice
PSI-40-166-0.002mg0.002mg£300.00
Quantity:
PSI-40-166-0.01mg0.01mg£428.00
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Further Information

Additional Names:
VEGFD, VEGF-D, VEGFD, Vascular endothelial growth factor D, c-Fos-induced growth factor
Background:
VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Biological Activity:
Measured by its ability to bind recombinant human VEGFR3/Flt-4 Fc in a functional ELISA.
NCBI Gene ID #:
2277
NCBI Official Name:
c-fos induced growth factor (vascular endothelial growth factor D)
NCBI Official Symbol:
FIGF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_004460.1
Protein GI Number:
4758378
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O43915

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