ProSci

MTCH2 Recombinant Protein

Product Code:
 
PSI-95-118
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Mass Spectrometry
  • Neutralisation
  • Western Blot (WB)
Storage:
 
Store in working aliquots at -70°C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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PSI-95-118-0.05mg0.05mg£347.00
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Further Information

Additional Names:
MTCH2 Recombinant Protein: HSPC032, 2310034D24Rik, 4930539J07Rik, Mitochondrial carrier homolog 2
Application Note:
This recombinant protein can be used for WB and ELISA. For research use only.
Background:
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals (4-6), suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
Background References:
  • Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
  • Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
  • Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
  • Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 2005; 25:4579-90.
Buffer:
1X PBS containing 0.1% SDS
Fusion Tag:
Fusion Partner: C-terminal His-tag
NCBI Gene ID #:
56428
NCBI Official Name:
mitochondrial carrier homolog 2 (C. elegans)
NCBI Official Symbol:
Mtch2
NCBI Organism:
Mus musculus
Physical State:
Liquid
Predicted Molecular Weight:
19 kDa (Calculated)
Protein Accession #:
NP_055157
Protein GI Number:
5815347
Purity:
~95%
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q791V5

Documents