ProSci

IL-6 Recombinant Protein

Product Code:
 
PSI-40-466
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Rat
Storage:
 
The lyophilized IL-6 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
 

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CodeSizePrice
PSI-40-466-0.002mg0.002mg£300.00
Quantity:
PSI-40-466-0.01mg0.01mg£428.00
Quantity:
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Further Information

Additional Names:
ILg6, Ifnb2, Il-6, Interleukin-6, IL-6
Background:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Biological Activity:
The ED50 was determined by the dose - dependent stimulation of the proliferation of IL - 6 - dependent murine 7TD1 cells is < 0.01 ng/mL, corresponding to a specific activity of > 1 x 108 units/mg.
NCBI Gene ID #:
24498
NCBI Official Name:
interleukin 6
NCBI Official Symbol:
Il6
NCBI Organism:
Rattus norvegicus
Physical State:
Lyophilized
Protein Accession #:
NP_036721.1
Protein GI Number:
7549769
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P20607

Documents