ProSci

CD32 Antibody [6C4] (APC)

Product Code:
 
PSI-76-196
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
6C4
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-196-25tests25tests£404.00
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Further Information

Additional Names:
CD32, FCG2, FcGR, CD32A, CDw32, FCGR2, IGFR2, FCGR2A1, FCGR2A
Background:
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB. From alternative mRNA splicing, 6 isoforms of CD32 have been reported. CD32 is a 40 kDA polymorphic transmembrane glycoprotein expressed on monocytes, macrophages, graulocytes, B cells, and platelets. The receptor has low affinity toward IgG and is involved in immunomodulation, phagocytosis, and the inflammation response. The 6C4 antibody in a rosette blocking assay is reported to inhibit Ig binding
Background References:
  • VELY, F., GRUEL, N., MONCUIT, J., COCHET, O., ROUARD, H., DARE, S., ... TEILLAUD, J. L. (1997). A new set of monoclonal antibodies against human Fc-gamma RII (CD32) and Fc-gamma RIII (CD16): characterization and use in various assays.Hybridoma,16(6), 519-528.
  • Liebert, M. A. (1997). 6C4, 2B2, 3D3.Hybridoma,16(6).
  • Bouhlal, H., Martinvalet, D., Teillaud, J. L., Fridman, C., Kazatchkine, M. D., Bayry, J., ... Kaveri, S. V. (2014). Natural Autoantibodies to Fc-gamma Receptors in Intravenous Immunoglobulins.Journal of clinical immunology, 1-8.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
2212
NCBI Official Name:
Fc fragment of IgG, low affinity IIa, receptor (CD32)
NCBI Official Symbol:
FCGR2A
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity
SPECIFICITY:
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB.
Swissprot #:
P12318
User NOte:
Optimal dilutions for each application to be determined by the researcher.