ProSci

p53 (phospho Ser392) Antibody

Product Code:
 
PSI-80-018
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-p53 (Ser392) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-p53 (Ser392) Antibody. The lane on the right is treated with the antigen-specific peptide.

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PSI-80-018-0.1mg0.1mg£488.00
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Further Information

Additional Names:
Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, Tumor suppressor p53
Application Note:
Western Blot: 1:500~1:1000
Background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
Background References:
  • Choi DW, et al. (2013) Mol Cell 51, 374-85
  • Bagashev A, et al. (2013) Cell Cycle 12, 1569-77
  • Shahar OD, et al. (2013) PLoS One 8, e78472
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
p53 (phospho Ser392) antibody was raised against a peptide sequence around phosphorylation site of serine 392 (P-D-S (p)-D) derived from Human p53.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7157
NCBI Official Name:
tumor protein p53
NCBI Official Symbol:
TP53
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
NP_000537.3
Protein GI Number:
120407068
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of p53 only when phosphorylated at serine 392.
Swissprot #:
P04637