ProSci

PAK5/6 (phospho Ser602/Ser560) Antibody

Product Code:
 
PSI-79-921
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from HeLa cells (Lane 2), using PAK5/6 (Phospho-Ser602/Ser560) Antibody. The lane on the left is treated with antigen-specific peptide.
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Western blot analysis of extracts from HeLa cells (Lane 2), using PAK5/6 (Phospho-Ser602/Ser560) Antibody. The lane on the left is treated with antigen-specific peptide.

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PSI-79-921-0.1mg0.1mg£488.00
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Further Information

Additional Names:
PAK5, PAK 6, kinase PAK6
Application Note:
Western Blot: 1:500~1:1000
Background:
This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development.
Background References:
  • Yang F., J. Biol. Chem. 276:15345-15353(2001).
  • Wagner T., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
  • Sjoeblom T., Science 314:268-274(2006).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PAK5/6 (phospho Ser602/Ser560) antibody was raised against a peptide sequence around phosphorylation site of Serine 602/560 (R-K-S (p)-L-V) derived from Human PAK5/6.
Modifications:
Phospho-Specific
NCBI Gene ID #:
57144/56924
NCBI Official Name:
p21 protein (Cdc42/Rac)-activated kinase 5, p21 protein (Cdc42/Rac)-activated kinase 6
NCBI Official Symbol:
PAK5, PAK6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
75 kDa
Protein Accession #:
NP_065074.1
Protein GI Number:
24308191
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of PAK5/6 only when phosphorylated at serine 602/560.
Swissprot #:
Q9P286/Q9NQU5