CHOP (phospho Ser30) Antibody
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
C/EBP-homologous protein, DDIT3, GADD153, DNA-damage inducible transcript 3,
Western Blot: 1:500~1:1000
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.
- Ubeda M, Habener JF (2003) J Biol Chem 278, 40514-20
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CHOP (phospho Ser30) antibody was raised against a peptide sequence around phosphorylation site of serine30 (V-L-S (p)-S-D) derived from Human CHOP .
Phospho-Specific
1649
DNA-damage-inducible transcript 3
DDIT3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
NP_001181982.1
544022
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Phospho-Specific
The antibody detects endogenous level of CHOP only when phosphorylated at serine 30.
P35638