ProSci

PAK2 (phospho Ser197) Antibody

Product Code:
 
PSI-79-861
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Immunohistochemistry (IHC)
Storage:
 
Store antibody at -20°C for up to one year.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK2 (Phospho-Ser197) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK2 (Phospho-Ser197) antibody (left) or the same antibody preincubated with blocking peptide (right).

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PSI-79-861-0.1mg0.1mg£488.00
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Further Information

Additional Names:
gamma-PAK, PAK65, PAKI, PAK 2
Background:
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Background References:
  • Martin G.A., EMBO J. 14:1970-1978(1995).
  • The MGC Project Team; Genome Res. 14:2121-2127(2004).
  • Olsen J.V., Cell 127:635-648(2006).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PAK2 (phospho Ser197) antibody was raised against a peptide sequence around phosphorylation site of Serine 197 (T-R-S (p)-V-I) derived from Human PAK2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
5062
NCBI Official Name:
p21 protein (Cdc42/Rac)-activated kinase 2
NCBI Official Symbol:
PAK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
58 kDa
Protein Accession #:
NP_002568.2
Protein GI Number:
32483399
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of PAK2 only when phosphorylated at serine 197.
Swissprot #:
Q13177