ProSci

MAP3K7 (phospho Thr187) Antibody

Product Code:
 
PSI-79-952
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from NIH-3T3 tissue using MAP3K7 (Phospho-Thr187) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from NIH-3T3 tissue using MAP3K7 (Phospho-Thr187) Antibody. The lane on the right is treated with the antigen-specific peptide.

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PSI-79-952-0.1mg0.1mg£488.00
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Further Information

Additional Names:
M3K7, MAP3K7, Mitogen-activated protein kinase kinase kinase 7, TGF-beta- activated kinase 1, kinase TAK1
Application Note:
Western Blot: 1:500~1:1000
Background:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.
Background References:
  • Shin MS, et al. (2009)Biochim Biophys Acta 1793, 1156-64
  • Liu Q, Busby JC, Molkentin JD (2009)Nat Cell Biol 11, 154-61
  • Kim SI, Kwak JH, Wang L, Choi ME (2008)J Biol Chem 283, 10753-63
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MAP3K7 (phospho Thr187) antibody was raised against a peptide sequence around phosphorylation site of threonine 187 (H-M-T (p)-N-N) derived from Human MAP3K7.
Modifications:
Phospho-Specific
NCBI Gene ID #:
6885
NCBI Official Name:
mitogen-activated protein kinase kinase kinase 7
NCBI Official Symbol:
MAP3K7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
NP_003179.1
Protein GI Number:
2924624
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of IMAP3K7 only when phosphorylated at threonine 187.
Swissprot #:
O43318