ProSci

CD3 delta Recombinant Protein

Product Code:
 
PSI-96-160
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Cynomolgus Monkey
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-160-0.1mg0.1mg£686.00
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Further Information

Additional Names:
CD3D, CD3-DELTA, T3D
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+?SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
Background References:
  • Gil J, et al., 2011, J Clin Invest, 121(10):3872-6.
  • Lu X, et al.,2011, Hematology, 16(3):185-9.
  • Kim ST, et al., 2010, J Immunol, 185(5):2951-9.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
102133701
NCBI Official Name:
CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol:
CD3D
NCBI Organism:
Macaca fascicularis
Physical State:
Lyophilized
Predicted Molecular Weight:
14.3 kDa
Protein Accession #:
Q95LI8
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q95LI8

Documents