ProSci

Ephrin A1 Recombinant Protein

Product Code:
 
PSI-96-256
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-256-0.1mg0.1mg£597.00
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Further Information

Additional Names:
EFNA1, Ephrin-A1, LERK-1, TNFAIP4, EPLG1, B61, ECKLG, EFL1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Ephrin-A1 (EFNA1) is also known as EPLG1, LERK1, TNFAIP4, Immediate early response protein B61, which belongs to the ephrin family. EFNA1 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA1 is cell surface GPI-bound ligand for Eph receptors, and is a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA1 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA1 plays an important role in angiogenesis and tumor neovascularization.
Background References:
  • Liu D.-P., et al., 2007, Int. J. Oncol. 30:865-871.
  • Wykosky J., et al., 2008, Oncogene 27:7260-7273.
Biological Activity:
Measured by its binding ability in a functional ELISA. When Recombinant Human EphA2 is coated at 4 μg/mL (100 μl/well), the concentration of rhEphrin-A1 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 0. 5 - 4 ng/mL.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
1942
NCBI Official Name:
ephrin-A1
NCBI Official Symbol:
EFNA1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
46 kDa
Protein Accession #:
NP_004419
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P20827

Documents