ProSci

TIM3 Recombinant Protein

Product Code:
 
PSI-96-724
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-724-0.1mg0.1mg£729.00
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Further Information

Additional Names:
HAVCR2, TIM3, TIMD3, FLJ14428, KIM3
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,? KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
Background References:
  • Monney, L. et al., 2002, Nature. 415: 536-41.
  • Sabatos, CA. et al., 2003, Nat. Immunol. 4: 1102-10.
  • Anderson, AC. et al., 2006, Curr. Opin. Immunol. 18: 665-9.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human TIM-3 (22-200), Fc Tag at 2 ug/mL (100 ul/well),can bind anti-TIM3 mAb with a linear range of 0.2-3 ng/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
84868
NCBI Official Name:
hepatitis A virus cellular receptor 2
NCBI Official Symbol:
HAVCR2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
46.5 kDa
Protein Accession #:
Q8TDQ0
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8TDQ0

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