ProSci

Frizzled 5 Recombinant Protein

Product Code:
 
PSI-96-334
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-334-0.1mg0.1mg£626.00
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Further Information

Additional Names:
FZD5, Frizzled-5, C2orf31, , Fz-5, hFz5, FzE5
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
Background References:
  • Hsieh J.C., et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551.
  • Hao H.X., et al., 2012, Nature 485:195-200.
Buffer:
PBS, pH 7.4
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
7855
NCBI Official Name:
frizzled class receptor 5
NCBI Official Symbol:
FZD5
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
42.6 kDa
Protein Accession #:
Q13467
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q13467

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