ProSci

PDL1 Recombinant Protein

Product Code:
 
PSI-96-599
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-599-0.025mg0.025mg£626.00
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Further Information

Additional Names:
PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
Background References:
  • Dong H., et al., 1999, Nat. Med. 5:1365-1369.
  • Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.
  • Nishimura H., et al., 2001, Trends?in?Immunology?22:265.?
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human PD-L1, Strep Tag at 5 ug/mL (100 ul/well) can bind Biotinylated Human PD-1, His Tag & Fc tag with a linear range of 2-60 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
C-Twin Strep Tag
NCBI Gene ID #:
29126
NCBI Official Name:
CD274 molecule
NCBI Official Symbol:
CD274
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
28.2 kDa
Protein Accession #:
NP_054862.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9NZQ7

Documents