ProSci

SLAMF 4 Recombinant Protein

Product Code:
 
PSI-96-001
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PSI-96-001-0.1mg0.1mg£686.00
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Further Information

Additional Names:
CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
Background References:
  • Nakajima H., et al., 1999, Eur. J. Immunol. 29:1676-1683.
  • Kubin M.Z., et al., 1999, Eur. J. Immunol. 29:3466-3477.
  • Boles K.S., et al., 1999, Tissue Antigens 54:27-34.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized rh CD244 / 2B4 at 2μg/ml (100μl/well) can bind human CD48. The EC50 of human CD48 is 0. 39μg/ml.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
51744
NCBI Official Name:
CD244 molecule, natural killer cell receptor 2B4
NCBI Official Symbol:
CD244
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
23.1 kDa
Protein Accession #:
NP_057466
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9BZW8

Documents